Renal dysplasia is a congenital or neonatal disease which causes maldevelopment of
the kidneys in utero, or early in life.
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Increased water consumption
Increased urination (dilute urine)
Poor doer, decreased appetite
Vomiting
Possibly prone to urinary tract infection |
Low urine specific gravity
Elevated creatinine and BUN
Small kidneys
Small, hyperechoic kidneys with or without cysts seen via abdominal ultrasound |
PLE is usually caused by inflammatory bowel disease or lymphangitis/lymphangiectasia.
In affected Wheatens there is a stimulation of the immune system in the bowel wall.
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Vomiting
Diarrhoea
Weight loss
Ascites, edema, pleural effusion |
Note that not all laboratory abnormalities are seen in every case. The most important
are indicated by an asterisk.
*Hypoalbuminemia, *Hypoglobulinemia, Hypocholesterolemia, Eosinophilia, Lymphopenia |
PLN is difficult to diagnose.
The initial stages of the disease may be mistaken for liver, glandular or other enteric
or kidney diseases.
Wheatens with PLN may have serious thromboembolic events before renal failure starts, even before
there is increased serum creatinine or BUN.
An abnormality of the glomeruli usually causes PLN.
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Listlessness/depression
Decreased appetite, vomiting, weight loss
Ascites, edema, pleural effusion
Thromboembolic phenomena and hypertension (less common)
Late - increased water consumption, increased urination |
Note that not all of the laboratory abnormalities are seen in every case. The most
important are indicated by an asterisk
*Hypoalbuminemia,
Hypercholesterolemia
Elevated MA (Microalbuminuria)
*Elevated urine protein/creatinine ratio
Late - Elevated SDMA, Creatinine, BUN |
Addison's disease (Hypoadrenocorticism) is the insufficient production and secretion
of hormones (glucocorticoids, mineralocorticoids) by the adrenal gland cortex.
The clinical signs are often non-specific and can mimic those of multiple other medical disorders.
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Listlessness/depression
Decreased appetite, vomiting, diarrhoea, weight loss
Inability to handle stress
Sudden collapse
Slow heart rate |
Decrease in Na/K ratio. (Sodium/potassium ratio)
Low resting cortisol and abnormal ACTH stimulation test
Possibly elevated SDMA, creatinine, BUN
Possibly low urine specific gravity |